MHC-I-presented non-canonical antigens expand the cancer immunotherapy targets in acute myeloid leukemia.

ABSTRACT: Identification of tumor neoantigens is indispensable for the development of cancer immunotherapies. However, we are still lacking knowledge about the potential neoantigens derived from sequences outside protein-coding regions. Here, we comprehensively characterized the immunopeptidome landscape by integrating multi-omics data in acute myeloid leukemia (AML). Both canonical and non-canonical MHC-associated peptides (MAPs) in AML were identified. We found that the quality and characteristics of ncMAPs are comparable or superior to cMAPs, suggesting ncMAPs are indispensable sources for tumor neoantigens. We further proposed a computational framework to prioritize the neoantigens by integrating additional transcriptome and immunopeptidome in normal tissues. Notably, 6 of prioritized 13 neoanti

SUBMITTER: Cai Y 

PROVIDER: S-EPMC11294462 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature