Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi K
PROVIDER: S-EPMC11294572 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Takahashi Katsuya K Lee Yongchan Y Fago Angela A Bautista Naim M NM Storz Jay F JF Kawamoto Akihiro A Kurisu Genji G Nishizawa Tomohiro T Tame Jeremy R H JRH
Nature communications 20240802 1
The principal effect controlling the oxygen affinity of vertebrate haemoglobins (Hbs) is the allosteric switch between R and T forms with relatively high and low oxygen affinity respectively. Uniquely among jawed vertebrates, crocodilians possess Hb that shows a profound drop in oxygen affinity in the presence of bicarbonate ions. This allows them to stay underwater for extended periods by consuming almost all the oxygen present in the blood-stream, as metabolism releases carbon dioxide, whose c ...[more]