Revealing the crucial roles of suppressive immune microenvironment in cardiac myxoma progression.

ABSTRACT: Cardiac myxoma is a commonly encountered tumor within the heart that has the potential to be life-threatening. However, the cellular composition of this condition is still not well understood. To fill this gap, we analyzed 75,641 cells from cardiac myxoma tissues based on single-cell sequencing. We defined a population of myxoma cells, which exhibited a resemblance to fibroblasts, yet they were distinguished by an increased expression of phosphodiesterases and genes associated with cell proliferation, differentiation, and adhesion. The clinical relevance of the cell populations indicated a higher proportion of myxoma cells and M2-like macrophage infiltration, along with their enhanced spatial interaction, were found to significantly contribute to the occurrence of embolism. The immune cell

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC11294589 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature