Exploring the interplay between antiretroviral therapy and the gut-oral microbiome axis in people living with HIV.

ABSTRACT: The gut and oral microbiome is altered in people living with HIV (PLWH). While antiretroviral treatment (ART) is pivotal in restoring immune function in PLWH, several studies have identified an association between specific antiretrovirals, particularly integrase inhibitors (INSTI), and weight gain. In our study, we explored the differences in the oral and gut microbiota of PLWH under different ART regimens, and its correlation to Body Mass Index (BMI). Fecal and salivary samples were collected from PLWH (n = 69) and healthy controls (HC, n = 80). We performed taxonomy analysis to determine the microbial composition and relationship between microbial abundance and ART regimens, BMI, CD4⁺T-cell count, CD4/CD8 ratio, and ART duration. PLWH showed significantly lower richness compar

SUBMITTER: Narayanan A 

PROVIDER: S-EPMC11294597 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature