Elucidating the roles of electrolytes and hydrogen bonding in the dewetting dynamics of the tear film.

ABSTRACT: This study explores the impact of electrostatic interactions and hydrogen bonding on tear film stability, a crucial factor for ocular surface health. While mucosal and meibomian layers have been extensively studied, the role of electrolytes in the aqueous phase remains unclear. Dry eye syndrome, characterized by insufficient tear quantity or quality, is associated with hyperosmolality, making electrolyte composition an important factor that might impact tear stability. Using a model buffer solution on a silica glass dome, we simulated physiologically relevant tear film conditions. Sodium chloride alone induced premature dewetting through salt crystal nucleation. In contrast, trace amounts of solutes with hydroxyl groups (sodium phosphate dibasic, potassium phosphate monobasic, and glucose)

SUBMITTER: Borkar S 

PROVIDER: S-EPMC11295001 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature