Iron regulatory protein 2 contributes to antimicrobial immunity by preserving lysosomal function in macrophages.

ABSTRACT: Colorectal cancer and Crohn's disease patients develop pyogenic liver abscesses due to failures of immune cells to fight off bacterial infections. Here, we show that mice lacking iron regulatory protein 2 (Irp2), globally (Irp2^-/-) or myeloid cell lineage (Lysozyme 2 promoter-driven, LysM)-specifically (Irp2^ΔLysM), are highly susceptible to liver abscesses when the intestinal tissue was injured with dextran sodium sulfate treatment. Further studies demonstrated that Irp2 is required for lysosomal acidification and biogenesis, both of which are crucial for bacterial clearance. In Irp2-deficient liver tissue or macrophages, the nuclear location of transcription factor EB (Tfeb) was remarkably reduced, leading to the downregulati

SUBMITTER: Cheng C 

PROVIDER: S-EPMC11295080 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature