Harnessing the Intrinsic Chemical Reactivity of the Mycotoxin Patulin for Immunosensing.

ABSTRACT: Mycotoxins are globally pervasive contaminants that threaten food safety worldwide. Regulatory authorities have established maximum permissible levels for certain mycotoxins, and their presence is routinely monitored throughout the food chain to ensure the provision of healthy food and safe feed for humans and animals. While immunoanalytical methods are essential for mycotoxin screening, monoclonal antibodies for the detection of patulin are notably absent. Moreover, leading immunodiagnostic companies currently do not offer rapid tests for patulin in their product portfolios. This deficiency in mycotoxin testing is primarily due to the electrophilic reactivity of patulin. In this study, we exploit this reactivity to develop an innovative strategy that targets the stable adduct formed by th

SUBMITTER: Duncan H 

PROVIDER: S-EPMC11295118 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature