M/P Helicity Switching and Chiral Amplification in Double-Helical Monometallofoldamers.

ABSTRACT: Short-stranded double-helical monometallofoldamers capable of M/P-switching were constructed by the complexation of two strands, each with two L-shaped units linked by a 2,2'-bipyridine, with a Zn(II) cation. The helix terminals of the "double-helical form" folded by π-π interactions can unfold in solution to equilibrate with the "open forms" that are favored at higher temperatures. Interestingly, the helical chirality of the monometallofoldamers with chiral side chains induced a single-handed helix sense and controlled M/P-switching depending on achiral solvent stimuli. For instance, the (M)-helicity was favored in nonpolarized solvents (toluene, hexane, Et₂O), whereas the (P)-helicity was favored in Lewis basic solvents (acetone, DMSO)

SUBMITTER: Matsumura K 

PROVIDER: S-EPMC11295176 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature