Antimicrobial Peptides Increase Line Tension in Raft-Forming Lipid Membranes.

ABSTRACT: The formation of phase separated membrane domains is believed to be essential for the function of the cell. The precise composition and physical properties of lipid bilayer domains play crucial roles in regulating protein activity and governing cellular processes. Perturbation of the domain structure in human cells can be related to neurodegenerative diseases and cancer. Lipid rafts are also believed to be essential in bacteria, potentially serving as targets for antibiotics. An important question is how the membrane domain structure is affected by bioactive and therapeutic molecules, such as surface-active peptides, which target cellular membranes. Here we focus on antimicrobial peptides (AMPs), crucial components of the innate immune system, to gain insights into their interaction with m

SUBMITTER: Koynarev VR 

PROVIDER: S-EPMC11295182 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature