Analysis of host factor networks during hepatitis B virus infection in primary human hepatocytes.

ABSTRACT:

Background

Chronic hepatitis B virus (HBV) infection affects around 250 million people worldwide, causing approximately 887,000 deaths annually, primarily owing to cirrhosis and hepatocellular carcinoma (HCC). The current approved treatments for chronic HBV infection, such as interferon and nucleos(t)ide analogs, have certain limitations as they cannot completely eradicate covalently closed circular DNA (cccDNA). Considering that HBV replication relies on host transcription factors, focusing on host factors in the HBV genome may provide insights into new therapeutic targets against HBV. Therefore, understanding the mechanisms underlying viral persistence and hepatocyte pathogenesis, along with the associated host factors, is crucial. In this study, we investigated novel therapeutic

SUBMITTER: Hwangbo S 

PROVIDER: S-EPMC11295519 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature