Single-cell peripheral immunoprofiling of lewy body and Parkinson's disease in a multi-site cohort.

ABSTRACT:

Background

Multiple lines of evidence support peripheral organs in the initiation or progression of Lewy body disease (LBD), a spectrum of neurodegenerative diagnoses that include Parkinson's Disease (PD) without or with dementia (PDD) and dementia with Lewy bodies (DLB). However, the potential contribution of the peripheral immune response to LBD remains unclear. This study aims to characterize peripheral immune responses unique to participants with LBD at single-cell resolution to highlight potential biomarkers and increase mechanistic understanding of LBD pathogenesis in humans.

Methods

In a case-control study, peripheral mononuclear cell (PBMC) samples from research participants were randomly sampled from multiple sites across the United States. The diagnosis groups comp

SUBMITTER: Phongpreecha T 

PROVIDER: S-EPMC11295553 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature