Disease severity drives risk of venous thrombotic events in women with sickle cell disease in a single-center retrospective study.

ABSTRACT:

Background

Estrogen-containing hormonal contraception (HC) is a well-established risk factor for venous thromboembolism (VTE). Women with sickle cell disease (SCD) also have an increased risk of VTE. However, it is unknown if exposure to HC exacerbates the risk of VTE in women with SCD.

Objectives

Assess the impact of HC on VTE risk in women with SCD and explore additional risk factors contributing to VTE development.

Methods

We analyzed a retrospective cohort of women of reproductive age (15-49 years) with SCD at the University of North Carolina from 2010 to 2022.

Results

We identified 370 women with SCD, and 93 (25.1%) had a history of VTE. Among 219 women exposed to HC, 38 of 184 (20.6%) had a VTE while actively using HC, whereas 20 of 151 (13.2%) women neve

SUBMITTER: Light J 

PROVIDER: S-EPMC11295566 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature