Homocysteine, blood pressure and gene-diet interactions in relation to vascular function measures of black South Africans.

ABSTRACT:

Background and aims

We investigated circulating homocysteine (Hcy), a cardiovascular disease (CVD) risk factor, examining its dietary associations to provide personalized nutrition advice. This study addressed the inadequacy of current dietary interventions to ultimately address the disproportionately high incidence of CVD in Black populations.

Methods and results

Cross-sectional analyses of 1,867 Black individuals of the PURE-SA study allowed the identification of dietary intake and cardiovascular measure interactions on three sub-categories: (1) normal blood pressure (BP), hypertension or Hcy-related hypertension (H-type), (2) low, normal or high Hcy concentrations, and (3) Hcy-related genetic combinations. Favorable body composition, but adverse dietary intake and cardiov

SUBMITTER: du Plessis JP 

PROVIDER: S-EPMC11295634 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature