Differential methylation patterns in paternally imprinted gene promoter regions in sperm from hepatitis B virus infected individuals.

ABSTRACT: Hepatitis B virus (HBV) infection poses a substantial threat to human health, impacting not only infected individuals but also potentially exerting adverse effects on the health of their offspring. The underlying mechanisms driving this phenomenon remain elusive. This study aims to shed light on this issue by examining alterations in paternally imprinted genes within sperm. A cohort of 35 individuals with normal semen analysis, comprising 17 hepatitis B surface antigen (HBsAg)-positive and 18 negative individuals, was recruited. Based on the previous research and the Online Mendelian Inheritance in Man database (OMIM, https://www.omim.org/ ), targeted promoter methylation sequencing was employed to investigate 28 paternally imprinted genes associated with various diseases. Bioinformatic an

SUBMITTER: Wu B 

PROVIDER: S-EPMC11295637 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature