FAM65A promotes the progression and growth of lung squamous cell carcinoma in vivo and vitro.

ABSTRACT:

Backgrounds

Currently, family with sequence similarity 65 member A (FAM65A) is reported as a pivotal regulator in various cancers. However, the effect of FAM65A in lung squamous cell carcinoma (LSCC) is still unclear, the prime objective of this research is to explore the role of FAM65A in LSCC.

Methods

Gene expression data and correlated clinical information were downloaded from the public database and the expression of FAM65A was detected. The expression of FAM65A was also detected in our collected clinical samples and LSCC cell lines. Survival package of R language was used to determine the survival significance of FAM65A. Proteins expression level was determined via western blot assay. Cell function experiments and in vivo experiments were performed to explore the effect

SUBMITTER: Chen F 

PROVIDER: S-EPMC11295694 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature