Poly-basic peptides and polymers as new drug candidates against Plasmodium falciparum.

ABSTRACT:

Background

Plasmodium falciparum, the malaria-causing parasite, is a leading cause of infection-induced deaths worldwide. The preferred treatment approach is artemisinin-based combination therapy, which couples fast-acting artemisinin derivatives with longer-acting drugs, such as lumefantrine, mefloquine, and amodiaquine. However, the urgency for new treatments has risen due to the parasite's growing resistance to existing therapies. In this study, a common characteristic of the P. falciparum proteome-stretches of poly-lysine residues, such as those found in proteins related to adhesion and pathogenicity-is investigated for its potential to treat infected erythrocytes.

Methods

This study utilizes in vitro culturing of intra-erythrocytic P. falciparum to assess the ability of

SUBMITTER: Sivakumar R 

PROVIDER: S-EPMC11295857 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature