Paternal obesity induces changes in sperm chromatin accessibility and has a mild effect on offspring metabolic health.

ABSTRACT: The increasing global burden of metabolic disorders including obesity and diabetes necessitates a comprehensive understanding of their etiology, which not only encompasses genetic and environmental factors but also parental influence. Recent evidence has unveiled paternal obesity as a contributing factor to offspring's metabolic health via sperm epigenetic modifications. In this study, we investigated the impact of a Western diet-induced obesity in C57BL/6 male mice on sperm chromatin accessibility and the subsequent metabolic health of their progeny. Utilizing Assay for Transposase-Accessible Chromatin with sequencing, we discovered 450 regions with differential accessibility in sperm from obese fathers, implicating key developmental and metabolic pathways. Contrary to expectations, these

SUBMITTER: Tahiri I 

PROVIDER: S-EPMC11296027 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature