Human effector CD8⁺ T cells with an activated and exhausted-like phenotype control tumour growth in vivo in a humanized tumour model.

ABSTRACT:

Background

Humanized tumour models could be particularly valuable for cancer immunotherapy research, as they may better reflect human-specific aspects of the interfaces between tumour and immune system of human cancer. However, endogenous antitumour immunity in humanized models is still largely undefined.

Methods

We established an autologous humanized mouse tumour model by using NSG mice reconstituted with human immune cells from hematopoietic progenitors and tumours generated from transformed autologous human B cells. We demonstrate growth of solid lymphoid tumours after subcutaneous implantation, infiltration by endogenous human immune cells and immunocompetence of the model.

Findings

We found human T cell subsets described in human cancer, including progenitor exha

SUBMITTER: Mietz J 

PROVIDER: S-EPMC11296066 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature