Real-world anti-seizure treatment and adverse events among individuals living with drug-resistant focal epilepsy in the United States.

ABSTRACT:

Objective

This study aimed to understand how people living with drug-resistant focal epilepsy (DRE) navigate through lines of antiseizure medications (ASM) and experience adverse events (AEs) in the real-world setting in the United States.

Methods

A retrospective study was conducted with medical chart data from clinical practices in the United States. Eligible adults had a confirmed diagnosis of DRE and initiated a third-line ASM therapy between January 2013 and January 2020 (i.e., the index date). Subjects must have medical history data available for ≥1 year prior to (the baseline) and ≥2 years after the index date (the follow-up). Treatment patterns were captured from first to fourth lines. After the emergence of drug resistance, time to ASM discontinuation, reasons for di

SUBMITTER: Mao J 

PROVIDER: S-EPMC11296083 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature