Treatment simplification to optimize cenobamate effectiveness and tolerability: A real-world retrospective study in Spain.

ABSTRACT:

Objective

This study aimed to explore the impact of co-antiseizure medication (co-ASM) optimization on the effectiveness and tolerability of adjunctive cenobamate (CNB) in patients with drug-resistant epilepsy in a real-world setting.

Methods

This unicentric, retrospective, observational study included adults with focal-onset seizures who had received ≥2 previous ASMs. The main effectiveness endpoints included responder rates and seizure frequency reduction at 3, 6, and 12-month visits. The number of co-ASMs and defined daily dose (DDD) were analyzed at every visit. Safety endpoints included adverse drug reactions (ADRs).

Results

Thirty-four patients with a median epilepsy duration of 22 years and a median of 15.5 seizures/month were analyzed. The median number of pri

SUBMITTER: Rodriguez-Uranga JJ 

PROVIDER: S-EPMC11296129 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature