Efficacy and safety of add-on antiseizure medications for focal epilepsy: A network meta-analysis.

ABSTRACT:

Objective

Several antiseizure medications (ASMs) have been approved for the treatment of focal epilepsy. However, there is a paucity of evidence on direct comparison of ASMs. We evaluated the comparative efficacy and safety of all approved add-on ASMs for the treatment of focal epilepsy using network meta-analysis.

Methods

Data through extensive literature search was retrieved from PubMed, Embase, Cochrane, and ClinicalTrial.gov databases using predefined search terms from inception through March 2023. PRISMA reporting guidelines (CRD42023403450) were followed in this study. Efficacy outcomes assessed were ≥50%, ≥75%, and 100% responder rates. Patient retention rate and safety outcomes such as overall treatment-emergent adverse events (TEAEs) and individual TEAEs were assess

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11296132 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature