Nuclear receptor Rev-erbα role in fine-tuning erythropoietin gene expression.

ABSTRACT:

Abstract

The regulation of red blood cell (RBC) homeostasis by erythropoietin (EPO) is critical for O2 transport and maintaining the adequate number of RBCs in vertebrates. Therefore, dysregulation in EPO synthesis results in disease conditions such as polycythemia in the case of excessive EPO production and anemia, which occurs when EPO is inadequately produced. EPO plays a crucial role in treating anemic patients; however, its overproduction can increase blood viscosity, potentially leading to fatal heart failure. Consequently, the identification of druggable transcription factors and their associated ligands capable of regulating EPO offers a promising therapeutic approach to address EPO-related disorders. This study unveils a novel regulatory mechanism involving 2 pivotal nucle

SUBMITTER: Kumar S 

PROVIDER: S-EPMC11296239 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature