Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat <i>Streptococcus pyogenes</i> skin and soft tissue infection.

ABSTRACT: We have developed GmPcides from a peptidomimetic dihydrothiazolo ring-fused 2-pyridone scaffold that has antimicrobial activities against a broad spectrum of Gram-positive pathogens. Here, we examine the treatment efficacy of GmPcides using skin and soft tissue infection (SSTI) and biofilm formation models by Streptococcus pyogenes. Screening our compound library for minimal inhibitory (MIC) and minimal bactericidal (MBC) concentrations identified GmPcide PS757 as highly active against S. pyogenes. Treatment of S. pyogenes biofilm with PS757 revealed robust efficacy against all phases of biofilm formation by preventing initial biofilm development, ceasing biofilm maturation and eradicating mature biofilm. In a murine model of S. pyogenes SSTI, subcutaneous deliv

SUBMITTER: Zou Z 

PROVIDER: S-EPMC11296344 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature