A comparative cross-platform analysis of cuproptosis-related genes in human nonobstructive azoospermia: An observational study.

ABSTRACT: This study aimed to identify novel biomarkers associated with cuproptosis in human nonobstructive azoospermia (NOA). We obtained 4 NOA microarray datasets (GSE145467, GSE9210, GSE108886, and GSE45885) from the NCBI Gene Expression Omnibus database and merged them into training set. Another NOA dataset (GSE45887) was used as validation set. Differentially expressed cuproptosis-related genes were identified from training set. Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway analyses were conducted. Least absolute shrinkage and selection operator regression and support vector machine-recursive feature elimination were used to identify hub cuproptosis-related genes. We calculated the expression of the hub cuproptosis-related genes in both validation set and patients w

SUBMITTER: Jiang S 

PROVIDER: S-EPMC11296415 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature