Immune checkpoints and pancreatic beta cell dysfunction in HIV.

ABSTRACT: We explored the impact of immune dysregulation on pancreatic beta cell injury in HIV patients. Analyzing 105 participant samples, we observed lower IL-21 levels and elevated immune checkpoint levels (e.g. PD-1, CD27+, CD40+) in untreated HIV patients. Notably, soluble TIM-3 correlated positively with improved beta cell function and inversely with beta cell stress, suggesting its potential role in beta cell protection in untreated HIV.

SUBMITTER: Pryke LA 

PROVIDER: S-EPMC11296497 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature