<i>LGG</i> promotes activation of intestinal ILC3 through TLR2 receptor and inhibits <i>salmonella typhimurium</i> infection in mice.

ABSTRACT: Salmonella is a foodborne pathogen that causes disruption of intestinal mucosal immunity, leading to acute gastroenteritis in the host. In this study, we found that Salmonella Typhimurium (STM) infection of the intestinal tract of mice led to a significant increase in the proportion of Lacticaseibacillus, while the secretion of IL-22 from type 3 innate lymphoid cells (ILC3) increased significantly. Feeding Lacticaseibacillus rhamnosus GG (LGG) effectively alleviated the infection of STM in the mouse intestines. TLR2^-/- mice experiments found that TLR2-expressing dendritic cells (DCs) are crucial for LGG's activation of ILC3. Subsequent in vitro experiments showed that heat-killed LGG (HK-LGG) could promote DCs

SUBMITTER: Wang J 

PROVIDER: S-EPMC11296546 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature