The contribution of second primary cancers to the mortality of patients with a first primary breast cancer.

ABSTRACT:

Purpose

Second primary cancers (SPCs) are estimated to affect nearly 5% of patients with breast cancer within 10 years of their diagnosis. This study aimed to estimate the contribution of SPCs to the mortality of patients with a breast first primary cancer (FPC).

Methods

A population-based cohort of 17,210 patients with a breast FPC diagnosed between 2000 and 2010 was followed for SPCs (31/12/2015) and vital status (30/06/2021). Patients diagnosed with an SPC (265 synchronous and 897 metachronous, ≤ 1 and > 1 year after the FPC, respectively) were matched (1:3, by five-year age group and year of breast FPC diagnosis) to those without an SPC and alive when the corresponding SPC was diagnosed.

Results

Significantly higher hazards of death were found among patients with

SUBMITTER: Goncalves E 

PROVIDER: S-EPMC11297125 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature