Circadian disruption reduces MUC4 expression via the clock molecule BMAL1 during dry eye development.

ABSTRACT: Circadian disruption, as a result of shiftwork, jet lag, and other lifestyle factors, is a common public health problem associated with a wide range of diseases, such as metabolic disorders, neurodegenerative diseases, and cancer. In the present study, we established a chronic jet lag model using a time shift method every 3 days and assessed the effects of circadian disruption on ocular surface homeostasis. Our results indicated that jet lag increased corneal epithelial defects, cell apoptosis, and proinflammatory cytokine expression. However, the volume of tear secretion and the number of conjunctival goblet cells did not significantly change after 30 days of jet lag. Moreover, further analysis of the pathogenic mechanism using RNA sequencing revealed that jet lag caused corneal transmemb

SUBMITTER: Zeng H 

PROVIDER: S-EPMC11297157 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature