Dynamical and combinatorial coding by MAPK p38 and NFκB in the inflammatory response of macrophages.

ABSTRACT: Macrophages sense pathogens and orchestrate specific immune responses. Stimulus specificity is thought to be achieved through combinatorial and dynamical coding by signaling pathways. While NFκB dynamics are known to encode stimulus information, dynamical coding in other signaling pathways and their combinatorial coordination remain unclear. Here, we established live-cell microscopy to investigate how NFκB and p38 dynamics interface in stimulated macrophages. Information theory and machine learning revealed that p38 dynamics distinguish cytokine TNF from pathogen-associated molecular patterns and high doses from low, but contributed little to information-rich NFκB dynamics when both pathways are considered. This suggests that immune response genes benefit from decoding immune signaling dyn

SUBMITTER: Luecke S 

PROVIDER: S-EPMC11297158 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature