The nucleosome reference frame and standard geometries for octasomes.

ABSTRACT: There are over 533 nucleosome structures in the Research Collaboratory for Structural Bioinformatics (RCSB). Collectively, numerous variants and species are present, as are sub-nucleosomal and super-nucleosomal assemblies within the nucleosome family. The organization of the histones and DNA is highly conserved in all standard octasomes containing 145, 146, or 147 base pairs. This observation is used to establish a nucleosome reference frame that enables us to describe and compare the gross structure and organization of all nucleosomes. We observe that cumulative sums of Rise, Twist, and DNA arc length are linear functions of the base pair index with R2 values exceeding 0.999 for almost all octasome structures. These relationships enable us to readily compare the location and orientation o

SUBMITTER: Sun R 

PROVIDER: S-EPMC11297230 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature