Phenotypic heterogeneity follows a growth-viability tradeoff in response to amino acid identity.

ABSTRACT: In their natural environments, microorganisms mainly operate at suboptimal growth conditions with fluctuations in nutrient abundance. The resulting cellular adaptation is subject to conflicting tasks: growth or survival maximisation. Here, we study this adaptation by systematically measuring the impact of a nitrogen downshift to 24 nitrogen sources on cellular metabolism at the single-cell level. Saccharomyces lineages grown in rich media and exposed to a nitrogen downshift gradually differentiate to form two subpopulations of different cell sizes where one favours growth while the other favours viability with an extended chronological lifespan. This differentiation is asymmetrical with daughter cells representing the new differentiated state with increased viability. We characterise the m

SUBMITTER: Shabestary K 

PROVIDER: S-EPMC11297284 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature