Abrocitinib may improve itch and quality of life in patients with itch-dominant atopic dermatitis.

ABSTRACT:

Background

Patients with atopic dermatitis (AD) exhibit heterogeneous clinical phenotypes, reflecting different combinations of itch and lesional severity. AD with severe itch but clear-moderate lesions, also known as itch-dominant AD, is a common clinical phenotype.

Objectives

To evaluate abrocitinib efficacy in patients with moderate-to-severe AD who have itch-dominant AD.

Methods

This post hoc analysis includes pooled data from clinical trials of patients with moderate-to-severe AD receiving abrocitinib (100 or 200 mg) as monotherapy (phase 2b; phase 3 JADE MONO-1 and JADE MONO-2) or in combination with topical therapy (phase 3 JADE COMPARE). Data from the ongoing long-term JADE EXTEND trial (data cutoff April 2020) were also evaluated. Itch-dominant AD was defined

SUBMITTER: Silverberg JI 

PROVIDER: S-EPMC11297436 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature