Feline dystrophin-deficient muscular dystrophy misdiagnosed as Toxoplasma myositis.

ABSTRACT:

Case summary

A 6-month-old male entire domestic shorthair cat presented for presumptive Toxoplasma myopathy that was non-responsive to antiprotozoal therapy. Clinical features included marked macroglossia, dysphagia, regurgitation, truncal muscle hypertrophy, pelvic limb gait abnormalities and megaoesophagus. Relevant diagnostics included serial creatine kinase activity, cardiac troponin I, fluoroscopic swallow study and routine muscle histopathology. Ultimately, post-mortem histopathology with immunostaining demonstrated markedly decreased or absent staining for the rod and carboxy terminus of dystrophin, confirming a dystrophin-deficient muscular dystrophy (MD). The misdiagnosis of toxoplasmosis was based on an increased IgG titre and muscle histopathology submitted to a l

SUBMITTER: Reynolds RM 

PROVIDER: S-EPMC11297512 | biostudies-literature | 2024 Jul-Dec

REPOSITORIES: biostudies-literature