Lipolysis pathways modulate lipid mediator release and endocannabinoid system signaling in dairy cows' adipocytes.

ABSTRACT:

Background

As cows transition from pregnancy to lactation, free fatty acids (FFA) are mobilized from adipose tissues (AT) through lipolysis to counter energy deficits. In clinically healthy cows, lipolysis intensity is reduced throughout lactation; however, if FFA release exceeds tissue demands or the liver's metabolic capacity, lipid byproducts accumulate, increasing cows' risk of metabolic and infectious disease. Endocannabinoids (eCBs) and their congeners, N-acylethanolamines (NAEs), are lipid-based compounds that modulate metabolism and inflammation. Their synthesis and release depend upon the availability of FFA precursors and the abundance of synthesizing and degrading enzymes and transporters. Therefore, we hypothesized that eCB production and transcription of endocannabinoi

SUBMITTER: Myers MN 

PROVIDER: S-EPMC11297689 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature