Analysis of miR-497/195 cluster identifies new therapeutic targets in cervical cancer.

ABSTRACT:

Objective

miR-497/195, located at 17p13.1, is a highly conserved miRNA cluster whose abnormal expression is a key regulator of carcinogenesis. We performed a comprehensive analysis of the miR-497/195 cluster to determine its prognostic utility and role in cervical cancer (CC) using publicly available datasets.

Results

In silico analysis and validation revealed that this cluster is downregulated in CC. A total of 60 target genes of miR-497/195 cluster were identified as differentially expressed between normal and CC samples. ShinyGO, STRING, CytoHubba, Timer 2.0, HPA, and HCMBD were used for functional enrichment, PPIN network construction, hub gene identification, immune infiltration correlation, histopathological expression, and determination of the metastatic potential of

SUBMITTER: Karunakara SH 

PROVIDER: S-EPMC11297691 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature