Toxoplasma infection induces an aged neutrophil population in the CNS that is associated with neuronal protection.

ABSTRACT:

Background

Infection with the protozoan parasite Toxoplasma gondii leads to the formation of lifelong cysts in neurons that can have devastating consequences in the immunocompromised. In the immunocompetent individual, anti-parasitic effector mechanisms and a balanced immune response characterized by pro- and anti-inflammatory cytokine production establishes an asymptomatic infection that rarely leads to neurological symptoms. Several mechanisms are known to play a role in this successful immune response in the brain including T cell production of IFNγ and IL-10 and the involvement of CNS resident cells. This limitation of clinical neuropathology during chronic infection suggests a balance between immune response and neuroprotective mechanisms that collectively prevent clinical man

SUBMITTER: Bergersen KV 

PROVIDER: S-EPMC11297776 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature