Novel therapeutic targets: bifidobacterium-mediated urea cycle regulation in colorectal cancer.

ABSTRACT:

Background and purpose

Colorectal cancer (CRC) is a widespread malignancy with a complex and not entirely elucidated pathogenesis. This study aims to explore the role of Bifidobacterium in the urea cycle (UC) and its influence on the progression of CRC, a topic not extensively studied previously.

Experimental approach

Utilizing both bioinformatics and experimental methodologies, this research involved analyzing bacterial abundance in CRC patients in comparison to healthy individuals. The study particularly focused on the abundance of BA. Additionally, transcriptomic data analysis and cellular experiments were conducted to investigate the impact of Bifidobacterium on ammonia metabolism and mitochondrial function, specifically examining its regulation of the key UC gene, ALB.<

SUBMITTER: Nie X 

PROVIDER: S-EPMC11297826 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature