Relaxation and Noise-Driven Oscillations in a Model of Mitotic Spindle Dynamics.

ABSTRACT: During cell division, the mitotic spindle moves dynamically through the cell to position the chromosomes and determine the ultimate spatial position of the two daughter cells. These movements have been attributed to the action of cortical force generators which pull on the astral microtubules to position the spindle, as well as pushing events by these same microtubules against the cell cortex and plasma membrane. Attachment and detachment of cortical force generators working antagonistically against centring forces of microtubules have been modelled previously (Grill et al. in Phys Rev Lett 94:108104, 2005) via stochastic simulations and mean-field Fokker-Planck equations (describing random motion of force generators) to predict oscillations of a spindle pole in one spatial dimension. Usin

SUBMITTER: Hargreaves D 

PROVIDER: S-EPMC11297845 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature