A Basal Ganglia model for understanding working memory functions in healthy and Parkinson's conditions.

ABSTRACT: Working memory (WM) is considered as the scratchpad for reading, writing, and processing information necessary to perform cognitive tasks. The Basal Ganglia (BG) and Prefrontal Cortex are two important parts of the brain that are involved in WM functions, and both structures receive projections from dopaminergic nuclei. In this modelling study, we specifically focus on modelling the WM functions of the BG, the WM deficits in Parkinson's disease (PD) conditions, and the impact of dopamine deficiency on different kinds of WM functions. Though there are many experimental and modelling studies of WM properties, there is a paucity of models of the BG that provide insights into the contributions of the BG in WM functions. The proposed model of BG uses bistable flip-flop neurons to model striatal

SUBMITTER: Vigneswaran C 

PROVIDER: S-EPMC11297868 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature