Mass vaccination with reassortment-impaired live H9N2 avian influenza vaccine.

ABSTRACT: Avian influenza poses a severe threat to poultry production and global food security, prompting the development of vaccination programs in numerous countries. Modified live virus (MLV) vaccines, with their potential for mass application, offer a distinct advantage over existing options. However, concerns surrounding reversion, recombination, and unintended transmission have hindered the progress of MLV development for avian influenza in poultry. To address these concerns, we engineered reassortment-impaired, non-transmissible, safe, immunogenic, and protective MLVs through the rearrangement of internal gene segments and additional modifications to the surface gene segments HA and NA. The unique peptide marker aspartic acid-arginine-proline-alanine-valine-isoleucine-alanine-asparragine (DRP

SUBMITTER: Cargnin Faccin F 

PROVIDER: S-EPMC11297921 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature