Genome-wide association study of therapeutic response to statin drugs in cardiovascular disease.

ABSTRACT: Cardiovascular disease (CVD) is one of the main causes of death in the world. The increased level of blood cholesterol is significantly correlated to CVD incidents. Statins are a group of drugs that decrease the synthesis of cholesterol in the liver by inhibiting the final enzyme of the pathway named HMG-CoA reductase. Several investigations showed that different patients give different responses to the administration of statin drugs according to their genetic background. In this research study, using Genome-Wide Association Studies (GWAS) data analysis methods, such as the SimpleM statistical approach and genomic connection matrix, we tried to discover the novel candidate SNPs that were involved in response to statin drugs. The investigation was carried out using 3,221 cardiovascular pati

SUBMITTER: Dabiri H 

PROVIDER: S-EPMC11297937 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature