Hydrostatic pressure drives sprouting angiogenesis via adherens junction remodelling and YAP signalling.

ABSTRACT: Endothelial cell physiology is governed by its unique microenvironment at the interface between blood and tissue. A major contributor to the endothelial biophysical environment is blood hydrostatic pressure, which in mechanical terms applies isotropic compressive stress on the cells. While other mechanical factors, such as shear stress and circumferential stretch, have been extensively studied, little is known about the role of hydrostatic pressure in the regulation of endothelial cell behavior. Here we show that hydrostatic pressure triggers partial and transient endothelial-to-mesenchymal transition in endothelial monolayers of different vascular beds. Values mimicking microvascular pressure environments promote proliferative and migratory behavior and impair barrier properties that are

SUBMITTER: Al-Nuaimi DA 

PROVIDER: S-EPMC11297954 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature