Neuro-intestinal acetylcholine signalling regulates the mitochondrial stress response in Caenorhabditis elegans.

ABSTRACT: Neurons coordinate inter-tissue protein homeostasis to systemically manage cytotoxic stress. In response to neuronal mitochondrial stress, specific neuronal signals coordinate the systemic mitochondrial unfolded protein response (UPR^mt) to promote organismal survival. Yet, whether chemical neurotransmitters are sufficient to control the UPR^mt in physiological conditions is not well understood. Here, we show that gamma-aminobutyric acid (GABA) inhibits, and acetylcholine (ACh) promotes the UPR^mt in the Caenorhabditis elegans intestine. GABA controls the UPR^mt by regulating extra-synaptic ACh release through metabotropic GABA_B receptors GBB-1/2. We find that elevated ACh levels in animals that are GABA-deficient or lack ACh-degradative e

SUBMITTER: Cornell R 

PROVIDER: S-EPMC11297972 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature