Identification of TFRC as a biomarker for pulmonary arterial hypertension based on bioinformatics and experimental verification.

ABSTRACT:

Background

Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disease. However, there is a paucity of studies that reflect the available biomarkers from separate gene expression profiles in PAH.

Methods

The GSE131793 and GSE113439 datasets were combined for subsequent analyses, and batch effects were removed. Bioinformatic analysis was then performed to identify differentially expressed genes (DEGs). Weighted gene co-expression network analysis (WGCNA) and a protein-protein interaction (PPI) network analysis were then used to further filter the hub genes. Functional enrichment analysis of the intersection genes was performed using Gene Ontology (GO), Disease Ontology (DO), Kyoto encyclopedia of genes and genomes (KEGG) and gene set enrichment

SUBMITTER: Yang C 

PROVIDER: S-EPMC11298087 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature