Dataset Information

CTLA-4 expression on CD4⁺ lymphocytes in patients with sepsis-associated immunosuppression and its relationship to mTOR mediated autophagic-lysosomal disorder.

ABSTRACT:

Background

The aim of this study was to clarify the relationship between expression level of CTLA-4 on CD4⁺ T cells and sepsis-associated immunosuppression (SAI), and to elucidate the possible mechanism of mTOR pathway mediated autophagic-lysosomal disorder in regulating CTLA-4 expression.

Methods

We enrolled 63 sepsis patients admitted to our ICU between January 1 and June 30, 2023. Peripheral blood mononuclear cells were isolated from the patients within 24 hours of recruitment. Expression levels of mTOR, P62, LC3II, and CTLA-4 on circulating CD4⁺ T lymphocytes were quantitated using flow cytometry. The association of these markers and relationship between CTLA-4 expression and the incidence of SAI and 28-day mortality were comprehensively analyzed.

SUBMITTER: Cheng W

PROVIDER: S-EPMC11298341 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Dataset Information

CTLA-4 expression on CD4⁺ lymphocytes in patients with sepsis-associated immunosuppression and its relationship to mTOR mediated autophagic-lysosomal disorder.

Background

Methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

CTLA-4 expression on CD4+ lymphocytes in patients with sepsis-associated immunosuppression and its relationship to mTOR mediated autophagic-lysosomal disorder.

Background

Methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

CTLA-4 expression on CD4⁺ lymphocytes in patients with sepsis-associated immunosuppression and its relationship to mTOR mediated autophagic-lysosomal disorder.