Genetic predisposition to type 2 diabetes mellitus and aortic dissection: a Mendelian randomisation study.

ABSTRACT:

Background

This Mendelian randomization (MR) study aimed to explore the causal relationship between the genetic predisposition to type 2 diabetes mellitus (T2DM) and aortic dissection (AD), and to assess associations with genetically predicted glycemic traits. The study sought to verify the inverse relationship between T2DM and AD using a more robust and unbiased method, building on the observational studies previously established.

Materials and methods

The study employed a two-sample and multivariable MR approach to analyze genetic data from the DIAbetes Meta-ANalysis of Trans-Ethnic association studies (DIAMANTE) with 74,124 cases and 824,006 controls, and the Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) involving up to 196,991 individuals. For AD

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11298347 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature