Assessment of the therapeutic potential of Hsp70 activator against prion diseases using in vitro and in vivo models.

ABSTRACT:

Introduction

Prion diseases are deadly neurodegenerative disorders in both animals and humans, causing the destruction of neural tissue and inducing behavioral manifestations. Heat shock proteins (Hsps), act as molecular chaperones by supporting the appropriate folding of proteins and eliminating the misfolded proteins as well as playing a vital role in cell signaling transduction, cell cycle, and apoptosis control. SW02 is a potent activator of Hsp 70 kDa (Hsp70).

Methods

In the current study, the protective effects of SW02 against prion protein 106-126 (PrP^106-126)-induced neurotoxicity in human neuroblastoma cells (SH-SY5Y) were investigated. In addition, the therapeutic effects of SW02 in ME7 scrapie-infected mice were evaluated.

Results

The results sho

SUBMITTER: Zayed M 

PROVIDER: S-EPMC11298377 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature