Causality between major depressive disorder and functional dyspepsia: a two-sample Mendelian randomization study.

ABSTRACT:

Background

To investigate the causal relationship between major depression and functional dyspepsia using two-sample Mendelian randomization.

Methods

Data for major depression and functional dyspepsia were obtained from genome-wide association studies. We selected Single Nucleotide Polymorphisms (SNPs) strongly associated with severe depression. Mendelian randomization analysis was conducted using methods such as Inverse-Variance Weighted (IVW), MR-Egger, and Weighted Median Estimator (WME). Sensitivity analysis was performed to assess the robustness of the results.

Results

A total of 31 eligible SNPs were identified as instrumental variables for major depression. IVW analysis indicated a positive causal relationship between the two conditions (β = 0.328; SE = 

SUBMITTER: Du Y 

PROVIDER: S-EPMC11298389 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature