Unraveling the molecular landscape of lead-induced cochlear synaptopathy: a quantitative proteomics analysis.

ABSTRACT:

Introduction

Exposure to heavy metal lead can cause serious health effects such as developmental neurotoxicity in infants, cognitive impairment in children, and cardiovascular and nephrotoxic effects in adults. Hearing loss is one of the toxic effects induced by exposure to lead. Previous studies demonstrated that exposure to lead causes oxidative stress in the cochlea and disrupts ribbon synapses in the inner hair cells.

Methods

This study investigated the underlying mechanism by evaluating the changes in the abundance of cochlear synaptosomal proteins that accompany lead-induced cochlear synaptopathy and hearing loss in mice. Young-adult CBA/J mice were given lead acetate in drinking water for 28 days.

Results

Lead exposure significantly increased the hearing thresh

SUBMITTER: Bhatia P 

PROVIDER: S-EPMC11298392 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature