Metagenomic analysis demonstrates distinct changes in the gut microbiome of Kawasaki diseases children.

ABSTRACT:

Background

Kawasaki disease (KD) has been considered as the most common required pediatric cardiovascular diseases among the world. However, the molecular mechanisms of KD were not fully underlined, leading to a confused situation in disease management and providing precious prognosis prediction. The disorders of gut microbiome had been identified among several cardiovascular diseases and inflammation conditions. Therefore, it is urgent to elucidate the characteristics of gut microbiome in KD and demonstrate its potential role in regulating intravenous immunoglobulin (IVIG) resistance and coronary artery injuries.

Methods

A total of 96 KD children and 62 controls were enrolled in the study. One hundred forty fecal samples had been harvested from KD patients, including indivi

SUBMITTER: Han L 

PROVIDER: S-EPMC11298399 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature